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The safety of actonel sodium 5 mg daily in the treatment and prevention of glucocorticoid-induced osteoporosis was assessed in two randomized, double-blind, placebo-controlled multinational trials of 344 patients male and female 221 aged 18 to 85 years who had recently initiated oral glucocorticoid therapy less than or equal to 3 months, prevention study or were on long-term oral glucocorticoid therapy greater than or equal to 6 months, treatment study .

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