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the first dose response acute postural hypotension of prazosin may be exaggerated in patients who are receiving beta-adrenergic blockers, diuretics, or other antihypertensive agents.

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prazosin hydrochloride is used alone or in combination with other classes of antihypertensive agents in the management of hypertension.

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6 mg day given in 2 divided doses group 5 182 patients – diltiazem sr 120 – 360 mg day given in 2 divided doses group 2 186 patients – prazosin 4 – 20 mg day given in 2 divided doses group 2 186 patients – placebo there was washout period of 4 – 8 weeks before randomization patients were titrated over a period of 4 – 8 weeks to a dbp 90 mmhg or until they reached the maximum drug dose primary outcome attainment of blood pressure goal during titration dbp 90 mmhg and dbp of 95 mmhg at one year at one year, the following was seen primary outcome diltiazem – 59 , atenolol – 51 , clonidine – 50 , hctz – 46 , captopril – 42 , prazosin – 42 , placebo – 25 average blood pressure reduction at end of titration phase atenolol sbp 11 mmhg, dbp 12 mmhg average blood pressure reduction at end of titration phase placebo sbp 3 mmhg, dbp 5 mmhg the incidence of side effects with atenolol was similar to that of placebo 3 .

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prazosin alpha-1 antagonist was being used to treat hypertension and coronary heart failure was also dosed appropriately.

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