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Secondary endpoints, such as reduced dyspnea, in the high-dose group may edge the clinician towards using a higher dose of furosemide, with confidence that safety outcomes, including renal dysfunction and the composite endpoints, remain unaffected.

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the authors suggest that activation of the calcium-sensing receptor in the thick ascending limb of henle in these cases was responsible for the metabolic abnormalities similar to hypercalcemia and furosemide.

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