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Hydrochlorothiazide, hctz; metoprolol moderate concomitant use of a thiazide diuretiic, or the related drug metolazone, with a loop diuretic can cause additive electrolyte and fluid loss.

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in addition, toprol-xl administered at a dose of 50 mg once daily lowered blood pressure 24-hours post-dosing in placebo-controlled studies.

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