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Because of the above and because of the known effects of nonsteroidal anti-inflammatory drugs nsaids on the fetal cardiovascular system closure of the ductus arteriosus , avoid aspirin and extended-release dipyridamole in the third trimester of pregnancy see use in specific populations 8.

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patients should be cautioned about the concomitant use of fluoxetine and nsaids, aspirin, warfarin, or other drugs that affect coagulation since combined use of psychotropic drugs that interfere with serotonin reuptake and these agents have been associated with an increased risk of bleeding see warnings and precautions 5.

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in 2007, the american diabetes association ada and the american heart association aha jointly recommended that aspirin therapy 75 162 mg day be used as a primary prevention strategy in those with diabetes at increased cardiovascular risk, including those who are over 40 years of age or who have additional risk factors family history of cvd, hypertension, smoking, dyslipidemia, or albuminuria 8 .

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contraindicated in patients who are allergic to aspirin or other nsaids, gastrointestinal bleeding, kidney or liver disease, asthma, dehydration, pregnancy, lactation.

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