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a direct comparison of stavudine with zidovudine, each in combination with lamivudine and indinavir as initial therapy, found no difference in the two regimens in maintaining viral load suppression at 48 weeks.

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irinotecan major indinavir is a strong cyp3a4 inhibitor; irinotecan is a cyp3a4 substrate.

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a lipodystrophy syndrome has been commonly reported with indinavir and other protease inhibitors combined with nrtis, but it has also been reported in many protease inhibitor-naive patients, and a definitive causal link has not been established between the syndrome and protease inhibitors.

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