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hepatic impairment published reports on the pharmacokinetics of intravenous colchicine in patients with severe chronic liver disease, as well as those with alcoholic or primary biliary cirrhosis, and normal renal function suggest wide inter-patient variability.

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indeed, we recorded an increased i ca in colchicine-treated ventricular myocytes even just after rupture of the patch see figure 7 in reference 18 18 that argues against the dialysis dependence of microtubule-disruption effects.

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increased colchicine concentrations; fatal colchicine toxicity reported 152 161 162.

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