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The information from table 2 included under adverse reactions is based on data from the continuous dosing trial at the recommended dose of sarafem sarafem 20 mg, n 104; placebo, n 108 and data from the intermittent dosing trial of fluoxetine in pmdd sarafem 20 mg, n 86; placebo, n 88 .

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interactions of carvedilol with potent inhibitors of cyp2d6 isoenzyme such as quinidine, fluoxetine, paroxetine, and propafenone have not been studied, but these drugs would be expected to increase blood levels of the r enantiomer of carvedilol see clinical pharmacology .

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other drugs metabolised by cyp2d6 fluoxetine is a strong inhibitor of cyp2d6 enzyme, therefore concomitant therapy with drugs also metabolised by this enzyme system may lead to drug interactions, notably those having a narrow therapeutic index such as flecainide, propafenone and nebivolol and those that are titrated, but also with atomoxetine, carbamazepine, tricyclic antidepressants and risperidone.

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3 selective serotonin reuptake inhibitors include fluoxetine prozac , sertraline zoloft , paroxetine paxil , fluvoximine luvox , and read document.

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