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based on the capacity of all-trans-retinoic acid tretinoin to pro-mote the synthesis of glycosaminoglycans in normal skin and increase the deposition ofcollagen in the photodamaged dermis, kligman et al.

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induction of remission with tretinoin and or chemotherapy is associated with progressive disappearance of these cytogenetic abnormalities, although reverse transcription polymerase chain reaction rt-pcr tests indicate that tretinoin alone is usually unable to totally eradicate the leukaemic clone.

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60 and two in-vitro studies showed that tretinoin significantly inhibited the release of oxygen free radicals and the generation of superoxide anions.

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