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Thioridazine severe limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the qtc interval in rare instances.
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fluoxetine combined with olanzapine is known as symbyax.
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when olanzapine therapy follows clozapine therapy in such patients, monitoring of complete blood counts is recommended.
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because carbamazepine substantially induces the cytochrome p450 1a2 metabolism of olanzapine, 9 an increase in the dose of olanzapine may be needed in such combinations.
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in an analysis of 3 placebo controlled olanzapine monotherapy studies of adolescent patients, including those with schizophrenia 6 weeks or bipolar disorder manic or mixed episodes 3 weeks , for fasting hdl cholesterol, no statistically significant differences were observed between olanzapine treated patients and placebo treated patients.
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the magnitude of the differences in cost is reduced when medians rather than means were examined, but nonparametric analysis of ranked cost data still showed statistically significant differences, with higher va costs for olanzapine ranging from 3000 to 9000 across measures table 3 .
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