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hence, bioequivalence study of four drug fdc tablet was conducted using 22 healthy male volunteers according to who recommended protocol to determine bioavailability of rifampicin, isoniazid and pyrazinamide compared to standard separate combination at the same dose level.
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acetaminophen; caffeine; phenyltoloxamine; salicylamide major agents which induce the hepatic isoenzyme cyp2e1, such as isoniazid, may potentially increase the risk for acetaminophen-induced hepatotoxicity via generation of a greater percentage of acetaminophen s hepatotoxic metabolites.
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close contacts of tb patients, including health care workers newly infected patients whose skin test has turned positive in the past two years anyone who is hiv-positive with a positive ppd skin test; isoniazid may be given even if the ppd results are negative if there is a risk of exposure to active tuberculosis intravenous drug users, even if they are negative for hiv persons with positive ppd results and evidence of old disease on the chest x-ray who have never been treated for tb patients who have an illness or are taking a drug that can suppress the immune system persons with positive ppd results who have had intestinal surgery; have diabetes or chronic kidney failure; have any type of cancer; or are more than 10 below their ideal body weight.
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blood levels and or toxicity of propranolol may be increased by administration of innopran xl with substrates or inhibitors of cyp1a2, such as imipramine, cimetidine, ciprofloxacin, fluvoxamine, isoniazid, ritonavir, theophylline, zileuton, zolmitriptan, and rizatriptan.
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