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The prolonged binding of tamoxifen to the nuclear chromatin of these results in reduced dna polymerase activity, impaired thymidine utilization, blockade of estradiol uptake, and decreased estrogen response.

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in the national surgical adjuvant breast and bowel project nsabp b-14 trial, a randomized phase iii study of tamoxifen vs observation in women with hr-positive breast cancer, the levels of er expression, analyzed by quantitative reverse transcriptase polymerase chain reaction qrt-pcr analysis, was also predictive of tamoxifen benefit.

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i had horrible joint pain in my knee to the point where i had an mri on it, but as it turns out, the pain was the tamoxifen.

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